Figure 7.

The multidimensional nature of efficacy. Data for the maximal agonist effect (E_max) values for agonists in different assays are plotted as an x/y plot. In (a), data for stimulation of [³⁵S]GTPγS binding by agonists at the D₂ dopamine receptor in the presence of Na⁺ and in the absence of Na⁺ (with N-methyl-D-glucamine (NMDG) substitution) are given as E_max relative to dopamine (Lin et al., 2006). In (b), data for stimulation of phospholipase C and arachidonic acid (AA) release via agonists at the serotonin 5-HT2C receptor (Moya et al., 2007) are given as E_max relative to 5-hydroxytryptamine.