Figure 2.

Changes in systolic BP (SBP) (a and c) and heart rate (HR) (b) in water (control)- and fructose-drinking rats (FDR) from 6 to 16 weeks of age and effect of pioglitazone (PIO). (c) SBP at 16 weeks. SBP and HR were measured by the tail-cuff method biweekly. Each value represents the mean and vertical bars show s.e.mean. PIO at a dose of 2.5 or 10 mg kg⁻¹ day⁻¹ was administered p.o. for 2 weeks from 14 to 16 weeks of age. ^*P<0.01 vs control rats. ^†P<0.01 vs untreated FDR.