Table 1.
Changes in body weight and food and liquid intake in water-drinking rats (control) and pioglitazone-treated control or 15% fructose-drinking rats and PIO-treated FDR
| 6 weeks old | 14 weeks old | 16 weeks old | |
|---|---|---|---|
| Body weight (g) | |||
| Control | 195.1±3.0 | 360.7±6.2 | 370.1±6.6 |
| Control+PIO (10 mg kg−1 day−1) | 196.3±2.5 | 368.4±6.1 | 368.2±5.7 |
| FDR | 194.0±1.9 | 370.6±7.1 | 369.9±3.2 |
| FDR+PIO (2.5 mg kg−1 day−1) | 197.2±2.1 | 370.2±5.2 | 370.3±4.5 |
| FDR+PIO (10 mg kg−1 day−1) | 196.7±3.8 | 374.2±9.2 | 371.9±12.7 |
| Food intake (g per 100 g BW per day) | |||
| Control | 7.3±3.3 | 4.9±1.3 | 5.2±2.8 |
| Control+PIO (10 mg kg−1 day−1) | 7.1±2.0 | 5.2±2.8 | 5.8±1.3 |
| FDR | 6.5±1.6 | 3.8±0.7** | 2.3±0.5** |
| FDR+PIO (2.5 mg kg−1 day−1) | 6.8±1.5 | 4.0±0.4* | 2.2±1.7** |
| FDR+PIO (10 mg kg−1 day−1) | 7.0±0.5 | 4.2±0.1* | 2.4±0.3** |
| Liquid intake (g per 100 g BW per day) | |||
| Control | 21.5±0.4 | 18.0±0.4 | 19.5±3.3 |
| Control+PIO (10 mg kg−1 day−1) | 20.8±2.9 | 17.7±1.4 | 20.1±2.0 |
| FDR | 22.0±1.7 | 16.1±2.3** | 15.0±1.0* |
| FDR+PIO (2.5 mg kg−1 day−1) | 23.2±1.2 | 14.1±0.7** | 15.3±2.8* |
| FDR+PIO (10 mg kg−1 day−1) | 19.1±0.3 | 13.7±2.8** | 16.1±3.1* |
Abbreviations: BW, body weight; FDR, fructose-drinking rats; PIO, pioglitazone.
Normal water or 15% fructose was given from 6 to 16 weeks as drinking solution. Pioglitazone at a dose of 2.5 or 10 mg kg−1 day−1 was administered p.o. for 2 weeks from 14 to 16 weeks of age. Values are expressed as the mean±s.e.mean of n results. Control, n=6; PIO-treated, n=6; FDR, n=8 and PIO-treated FDR, n=12. *P<0.05, **P< 0.01 vs control.