Table 2.

Random effect analysis of the effects of GBP on BOLD responses in the brain

Brain region	Localization	Bregma (mm)	Cluster size (voxel)	Z score	t value
Infusion 1 versus baseline (from Figure 3)
Thalamus	Left	−3.3	3	3.2	4.81
Thalamus	Right	−3.3	6	3.49	6.13
Thalamus	Midline	−3.3	29	3.75	7.21
Habenular nucleus	Midline	−4.3	∣	3.24	5.26
PAG	Midline	−5.3	∣	3.91	7.98
PAG	Midline	−6.3	∣	3.41	5.86
Tegmental area	Left	−8.3	14	3.59	6.52
Tegmental area	Left	−9.8	∣	3.32	5.51
Amygdaloid nucleus	Right	−3.3	3	3.51	6.22
Ectorhinal cortex	Right	−4.3	6	3.27	5.08
Entorhinal cortex	Right	−5.3	∣	3.25	5.28
CA1	Left	−5.3	64	3.79	7.4
Subiculum/CA1	Left	−6.3		4.27	10.19
Infusion 2 versus baseline (from Figure 4)
Thalamus	Midline	−1.3	158 (cluster A)	3.78	7.33
Thalamus	Midline	−2.3	∣	3.28	5.39
Thalamus	Right	−2.3	∣	3.11	4.84
Thalamus	Midline	−3.3	∣	3.99	8.46
Thalamus	Right	−3.3	∣	3.57	6.42
Thalamus	Midline	−4.3	∣	3.69	6.96
Thalamus	Right	−4.3	∣	3.46	6.01
PAG	Midline	−5.3	∣	4.08	8.94
Thalamus	Left	−4.3	9	3.15	4.98
PAG	Midline	−6.3	6	3.29	5.44
PAG	Midline	−7.3	∣	3.22	5.19
Tegmental area	Left	−8.3	108	4.18	9.55
Tegmental area	Left	−9.8	∣	4.42	11.24
Amygdaloid nucleus	Right	−4.3	5	3.32	5.52
CA1	Left	−5.3	42	3.24	5.24
CA3	Left	−5.3	∣	3.1	4.83
Subiculum/CA1	Left	−6.3	∣	3.4	5.79
ECIC	Left	−8.3	12	3.69	6.95
Infusion 2 versus infusion 1
Thalamus	Right	−3.3	99 (cluster B)	3.89	5.74
Thalamus	Right	−3.3	∣	3.53	6.27
Thalamus	Right	−4.3	∣	3.25	5.27
PAG	Midline	−5.3	∣	3.78	7.36
Tegmental area	Left	−8.3	34	4.13	9.24
Geniculate nucleus	Left	−4.3	19	3.79	7.43
CA3	Left	−5.3	1	3.2	5.13
ECIC/subiculum	Left	−7.3	9	3.31	5.47

Abbreviations: BOLD, blood oxygen level dependent; ECIC, external cortex of the inferior colliculus; GBP, gabapentin; PAG, periaqueductal grey.

Infusion 1 or 2 was compared to baseline and infusion 2 was compared to infusion 1.

Regions in italics refer to areas depicting decreases in BOLD signal intensity.