Table 1.

Characteristic Patterns of EBV Gene Expression in Normal and Lesional Tissue

Cell or tissue type	Typical EBV gene expression*
AIDS-related plasmablastic lymphoma	Type 0 latency (EBERs, BARTs)
Burkitt lymphoma	Type I latency (EBNA1, LMP2, EBERs, BARTs)
Hodgkin lymphoma	Type II latency (EBNA1, LMP1, LMP2, EBERs, BARTs)
AIDS-related Burkitt or primary effusion lymphoma	Type II
Peripheral T cell lymphoma	Type II
NK/T cell lymphoma, nasal type	Type II
Nasopharyngeal carcinoma	Type II plus BARF1
Gastric adenocarcinoma	Type II plus BARF1
Post-transplant lymphoproliferative disorder	Type III latency (EBNA1, −2, −3A, −3B, −3C; LMP1, LMP2, EBERs, BARTs)
AIDS-related immunoblastic or brain lymphoma	Type III
Infectious mononucleosis	Type III
Chronic active EBV infection	Type III
Lymphoblastoid cell lines in vitro	Type III
Oral hairy leukoplakia	Lytic infection (LMP1, LMP2, BZLF1, BMRF1, BHRF1, BCRF1, and other replication factors)
Remotely infected carriers
Circulating B cells	Type 0
Tonsil/mucosal B cells	Type II

^*Viral gene expression may be focal or variable in a given lesion.