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. 2008 May 5;105(20):7257–7262. doi: 10.1073/pnas.0706473105

Fig. 1.

Fig. 1.

Synergy of amylin and leptin in DIO-prone rats. (A–F) Cumulative food intake (A, C, and E) and changes in body weight (B, D, and F) after administration in HSD rats (n = 4 per group) (A and B) or in DIO-prone rats (C–F) of leptin (filled inverted triangles), vehicle (open circles), amylin (open triangles), PF(amylin)+leptin (filled circles), or amylin+leptin (filled squares) for 14 d (n = 6 per group) (A–D) or for 12 d (n = 7 per group) (E and F). (G and H) Percentage body fat (G) and lean (H) after 12-d treatment in DIO-prone rats. Mean ± SE: *, P < 0.05 vs. vehicle controls; #, P < 0.05 vs. vehicle controls and monotherapies.