Figure 1.

Nonpregnant wild-type (WT) mouse. Time course of indomethacin concentration in blood following treatment with single (a) (n=5) and repeated (b) (n=9) oral doses (2 mg kg⁻¹). In the latter case, the drug was given at 24-h intervals from days 0 to 3 and blood was collected for analysis just prior to each administration. Note that two animals were used simultaneously with every acute experiment, each yielding blood samples at different time intervals to build a complete concentration curve (for details, see Methods).