Figure 4.
Isolated ductus arteriosus from wild-type (WT) fetal mouse. Comparison of contractile responses to NG-nitro-L-arginine methyl ester (L-NAME) (100 μM) in control vs indomethacin (indo)-pretreated preparations in vivo (acute and chronic treatments). Baseline wall tension (mN mm−1) was as follows: control, 0; acute indomethacin, 0.04±0.02; chronic indomethacin, 0.01±0.01. For each group, the number of experiments is given above the columns, and a significant difference (P<0.01, ANOVA) between control and chronic indomethacin is indicated with an asterisk.