Figure 3.

JNJ-17156516 ((S)-(3-[5-(3,4-dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-2-m-tolyl-propionic acid) and dexloxiglumide suppressed the elevation of plasma amylase and lipase activity after bile duct ligation in the rat. The effects of JNJ-17156516 (a) and dexloxiglumide (b) on plasma amylase (top) and lipase activity (bottom) after bile duct ligation are shown as the mean±s.e.mean, n=5–9. A sham bile duct ligation group was included to control for surgical procedure. In these animals, a suture was placed around the bile duct but the bile duct was not ligated. Note that the plasma amylase and lipase activity are plotted on a log scale.