Fig. 2.

eCBs regulate neural progenitor proliferation in cortical VZ/SVZ. (A) CB₁R deletion significantly reduces the rate of neural progenitor proliferation, as defined by the density of BrdU⁺ cells in the VZ/SVZ. (B) Conversely, elevated eCB levels in FAAH^−/− mice (14) significantly increase neural progenitor proliferation. (C) Conditional CB₁R deletion in subcortical SVZ progenitors (arrows) (16) decreases the rate of Ki67⁺ progenitor proliferation (n = 3 per genotype). **, P < 0.01, compared with wild-type littermates. (Scale bar, 100 μm.)