Fig. 4.

Domain architectures of selected peptides involved in signal transduction in MED152. MED152_00100 is a hybrid two-component His kinase sensor with both a HEW type His kinase (HEW HK) and a response regulator (REC). It contains a phytochrome domain that detects red and far-red light in a number of organisms. PAC, PAS, and GAF domains are common components of phytochromes. HK is a His kinase domain with its cognate ATPase domain (HK ATPase). In MED152_08960, a BLUF domain (shown to sense blue light) is next to a DNA-interacting AraC-type helix-turn-helix domain (HTC AraC). CHASE3 is an extracellular sensory domain, and HAMP has been suggested to regulate signal transduction. CheB methylesterase and CheR methyltransferase are part of chemiotaxis signaling in bacteria. Solid bars represent transmembrane regions.