Table 1.
Percentage of myotubes displaying normal or disrupted sarcomeres after CMV promoter-driven cardiac TnT expression
% normal sarcomeres | % disrupted regions | |
---|---|---|
Control | 100 | 0 |
Wild-type cardiac TnT | 100 | 0 |
Truncated TnT mutant | 0 | 100 |
Ile79Asn mutant | 92.5 | 7.5 |
Arg92Gln mutant | 89 | 11 |
ΔGlu160 mutant | 91 | 9 |
Numbers in this table are based on counts of 1,000 myotubes. The truncated TnT is described in ref. 8. It results from a splicing error that removes the C-terminal 28 amino acids and replaces them with seven incorrect amino acids.