Figure 2.

(A) Ex vivo IFN-β gene therapy in KM12L4A cells (a), Huh7 cells (b), and ME180 cells (c). Mean tumor size was plotted versus time after tumor cell implantation. Mice were implanted with uninfected cells (■) or H5.110hIFNβ-infected cells at 1% (•) or 10% (▴). In those groups in which some mice were sacrificed, the tumor size is presented as the average with last value carried forward for the sacrificed animals. Discontinuation of plots reflects the death or sacrifice of all animals in a group. (B) Percentage survival of mice over the observation period of 70 days. a–c show the data generated with mice implanted with KM12L4A cells, Huh7 cells, and ME180 cells, respectively. Uninfected cells (■) or H5.110hIFNβ-infected cells at 1% (•) and 10% (▴).