Figure 2.

“Scattering” (motility) of MDCK cells expressing mutationally activated Met. Cells were cotransfected with a vector conferring resistance to G418, together with a vector encoding wild-type or mutationally activated Met, and selected in G418. (A) The percentage of colonies exhibiting a motile/scattered phenotype was recorded. The results represent the mean of two independent experiments in which a minimum of 100 colonies/sample were examined. (B) A representative nonscattered parental colony. (C) A representative “scattered” (motile) colony induced by mutationally activated Met (L1213V).