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Homing of hematopoietic progenitors. Freshly isolated wild-type BM cells (5 × 106 to 1 × 107) were injected into lethally irradiated wild-type (striated column) and P/E−/− (solid column) recipients. Progenitor homing was assayed as described in Materials and Methods. The percent of homed CFU-C activity, in two pooled experiments, is expressed per organ for (A) nonsplenectomized, n = 7 and (B) splenectomized mice, n = 9–12. ∗, P < 0.03; #, P = 0.006 compared with wild-type animals.
