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. 2008 Mar 3;154(1):204–215. doi: 10.1038/bjp.2008.57

Figure 1.

Figure 1

IN-PC synapses possess functional presynaptic CB1 receptors. (a) Continuous data traces showing effects of WIN55 (5 μM) and subsequent application of AM251 (2 μM) in the continued presence of WIN55 (5 μM) on control (CTL) mIPSCs (holding potential (VH)=−70 mV). Note that WIN55 decreased mIPSC frequency, whereas AM251 caused increases beyond basal levels. Time course for effect of WIN55 (5 μM) and AM251 (2 μM) on normalized mIPSC frequency (b) and normalized mIPSC amplitude (c) (both n=8±s.e.mean). (d) Cumulative frequency plots for effect of WIN55 (5 μM) and subsequent application of AM251 (2 μM) on control (CTL) mIPSC IEI (bin widths 5 ms) (all n=8±s.e.mean). (e) Bar graph showing summarized effects of WIN55 (1 μM; n=6±s.e.mean and 5 μM; n=8±s.e.mean) and of subsequent application of AM251 (2 μM, n=8±s.e.mean) in the continued presence of WIN55 (5 μM) on control (CTL, n=8±s.e.mean) normalized mIPSC frequency; *P<0.05, **P<0.01 (paired t-test or ANOVA).