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. 2008 Mar 3;154(1):204–215. doi: 10.1038/bjp.2008.57

Figure 2.

Figure 2

WIN55-induced inhibition at IN-PC synapses is reversed by Δ9-THCV. (a) Continuous data traces showing effects of WIN55 (5 μM) and subsequent application of Δ9-THCV (20 and 40 μM) in the continued presence of WIN55 (5 μM) on control (CTL) mIPSCs; VH=−70 mV. Δ9-THCV reversed WIN55-induced inhibition and increased mIPSC frequency beyond basal levels. (b) Example of time course for effects of WIN55 (5 μM) and subsequent application of Δ9-THCV (10–40 μM) on mIPSC frequency. (c) Bar graph showing summarized effects of WIN55 (5 μM, n=8±s.e.mean) and subsequent application of Δ9-THCV (5–58 μM; n=3–8±s.e.mean) in the continued presence of WIN55 (5 μM) on control (CTL, n=8±s.e.mean) normalized mIPSC frequency; *P<0.05, **P<0.01 vs WIN55, or vs CTL as shown (paired t-test or ANOVA).