Figure 3.
CB1-selective antagonists and Δ9-THCV applied alone increase inhibitory neurotransmission at IN-PC synapses. Continuous data traces showing effects of (a(i)) AM251 (2 μM), (b(i)) rimonabant (3 μM) and (c(i)) Δ9- THCV (10 μM) on control (CTL) mIPSCs; in all cases, VH=−70 mV. Note that each cannabinoid acted to increase mIPSC frequency. Corresponding time courses for effects of (a(ii)) AM251 (2 μM; n=6±s.e.mean), (b(ii)) rimonabant (3 μM; n=5±s.e.mean) and (c(ii)) Δ9-THCV (10 μM; n=6±s.e.mean).