Figure 3.

Comparison of the effect of rifampin and digoxin preincubation upon transepithelial [³H]digoxin (0.5 μCi ml⁻¹, total digoxin 100 nM) fluxes across confluent monolayers of T84 cells. Fluxes were determined over 1 h (as in Figure 2) following 72 h incubation with 10 μM rifampin (a), 100 nM digoxin (b) and 1 μM digoxin (c). ^*Significantly different from controls (0.1% DMSO vehicle); P<0.05. Data are expressed as±s.e.mean, n=6 replicates from an individual experiment. DMSO, dimethyl sulphoxide.