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. 2008 Mar 3;154(1):216–225. doi: 10.1038/bjp.2008.73

Figure 4.

Figure 4

Gabapentin (GBP; 1-(aminomethyl) cyclohexaneacetic acid) enhances renal outer medullary potassium (ROMK1) channel activity through a protein kinase A (PKA)-dependent pathway. After 5 min pre-incubation in the on-cell configuration with PKA inhibitor (a) H89 (10 μM) or (b) KT5720 (2 μM), gabapentin failed to activate channel activity. (c) Percentage activation by gabapentin of ROMK1 channels in the absence (GBP) and presence (H89/GBP and KT5720/GBP) of a PKA inhibitor (n=6 for each group). *Indicates P<0.05 by ANOVA compared with the corresponding wild-type in the absence of gabapentin (control).