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Fetuin increased the CNI-1493-mediated suppression of serum TNF level in vivo. Fetuin (20 mg/kg) was coadministered with CNI-1493 (2.5 mg/kg) i.p. into BALB/c mice 1 hr before LPS (10 mg/kg) stimulation. Two hours after LPS stimulation, mice serum was collected and TNF levels were assayed by ELISA. Data shown are mean ± SEM of two independent experiments with five animals per group.
