Table 2.
The maximal contraction and EC50 to KCl, phenylephrine and U46619 in control, apocynin-treated control, STZ (55 mg kg−1)-treated, and apocynin- and STZ-treated rats
| Control rats | Apocynin-treated control rats | STZ-treated rats | Apocynin- and STZ-treated rats | |
|---|---|---|---|---|
| Maximal contraction (60 mM KCl, g) | 1.79±0.11 | 1.70±0.14 | 1.33±0.10* | 1.74±0.11 |
| EC50 to KCl (−log M) | 35.75±1.52 | 36.59±2.09 | 31.91±1.89 | 29.76±0.96 |
| Maximal contraction (10−5 M phenylephrine, g) | 2.12±0.11 | 1.91±0.12 | 1.72±0.13* | 2.03±0.12 |
| EC50 to phenylephrine (−log M) | 6.63±0.12 | 6.39±0.12* | 7.40±0.09* | 6.83±0.06 |
| Maximal contraction (10−6 M U46619, g) | 2.23±0.14 | 2.13±0.18 | 1.76±0.13* | 2.14±0.13 |
| EC50 to U46619 (−log M) | 7.51±0.04 | 7.70±0.09 | 8.05±0.15* | 7.60±0.06 |
Abbreviation: STZ, streptozotocin.
Data are shown as means±s.e.mean; n=6–10.
*Statistically significant differences from the rings of control rats (P<0.05).