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. 2008 Apr 14;154(3):652–662. doi: 10.1038/bjp.2008.108

Figure 5.

Figure 5

Comparison of effects of Calhex 231 on endothelium-dependent smooth muscle hyperpolarizations to calindol and 1-ethyl-2-benzimidazolinone (1-EBIO) in endothelium-intact mesenteric artery segments from control (ZL) and diabetic (ZDF) rats. (a) Typical trace obtained showing inhibition by 1 μM Calhex 231 of the responses to transient exposure to calindol (0.1–1 μM), but not to 1-EBIO (300 μM), in a segment of artery from a ZL rat. Levcromakalim (LK; 10 μM) was added at the end of the experiment to ascertain the myocyte viability. The tissue was exposed to Calhex 231 for the period indicated by the horizontal bar. (b) Graphical representation of data from four separate experiments of the type shown in panel a. Each column represents the mean membrane potential (m.p.) before (+ s.e.mean) and after (− s.e.mean) addition of calindol or 1-EBIO in the absence or presence of Calhex 231. *indicates ZDF response significantly different from corresponding ZL response. ZDL, Zucker diabetic fatty rat; ZL, Zucker lean.