Figure 2.

Superfusion experiments. (a) Effect of the 5-HT1A agonist 8-OH-DPAT and the 5-HT1A antagonist WAY 100635 on the inhibition of electrically evoked release of 5-[³H]HT from preloaded mesencephalic brain slices obtained from wild-type and knockout mice (mean ± SEM). The number of experiments per group is indicated at the bottom of each column. For each group, slices were obtained from five mice. Drug values were compared with control values unless otherwise indicated by a bracket, by using Student’s t test. (∗, P ≤ 0.05; ∗∗, P ≤ 0.01; ∗∗∗, P ≤ 0.001). (b) Effect of the 5-HT1B agonist CP93129 on the inhibition of electrically evoked release of 5-[³H]HT from preloaded hippocampus slices (mean ± SEM). The number of experiments per group is indicated in parentheses; P = 0.026 by using a two-tailed Student’s t test.; S1, electrically evoked release of 5-[³H]HT was not significantly different between wild-type and knockout mice.