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. 2008 Apr 14;154(4):882–889. doi: 10.1038/bjp.2008.97

Figure 5.

Figure 5

Effect of combined agonist and antagonist application on depolarization-dependent [Ca2+]i responses. (a) Sample recording illustrating the depolarization-dependent Ca2+ increases during co-exposure to suramin (8-(3-benzamido-4-methylbenzamido)-naphthalene-1,3,5-trisulphonic acid) and ADP. (b) Average peak [Ca2+]i increases induced by agonist or depolarization (−75 to 5 mV) for 1 μM ADP or a combination of 1 μM ADP and 10 μM of the specified antagonists. The responses to depolarization in the presence of ADP and either PPADS (pyridoxal phosphate-6-azo(benzene-2,4-disulphonic acid)), acetyl CoA (CoA-SH) or suramin, were significantly enhanced (*P<0.05 or **P<0.01) compared with those observed with ADP alone.