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. 2008 Apr 14;154(4):882–889. doi: 10.1038/bjp.2008.97

Figure 6.

Figure 6

Effect of allosteric P2Y1 modulators on depolarization-evoked Ca2+ release. (a) Effect of the allosteric potentiator PIT (2,2′-pyridylisatogen tosylate; 1 μM) and the allosteric inhibitor SCH202676 (N-(2,3-diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene) methanamine; 10 μM) on depolarization-evoked [Ca2+]i responses in the presence and absence of agonist (1 μM ADP). All test depolarizations were from a holding potential of −75 to 5 mV. (b) Sample record showing the block of ADP-induced voltage-dependent Ca2+ release by SCH202676 (N-(2,3-diphenyl-1,2,4-thiadiazol-5-(2H)-ylidene) methanamine).