Table 5.

Reversal of stress-induced hyperthermia in mice

T1 (°C)
rac-BHFF (p.o.)	Veh	3 mg kg−1	10 mg kg−1	30 mg kg−1	100 mg kg−1
n	9	8	8	8	8
Mean	37.43	37.71	37.65	37.63	37.74
s.e.mean	0.06	0.06	0.11	0.10	0.09
SIH, ΔT (T2−T1)
Mean	0.71	0.37	0.45	0.39	0.11
s.e.mean	0.05	0.13	0.14	0.08	0.09
Significance					***

Male NMRI mice received rac-BHFF at doses of 3, 10, 30 and 100 mg kg⁻¹ p.o., 1 h prior to T₁. Data are mean±s.e.mean based on eight animals per dose.

Veh, vehicle (10 mg kg⁻¹ of a 4:1:15 mixture containing Cremophor EL, 1,2-propanediol and distilled water), ^***P<0.001 vs vehicle, one-way ANOVA followed by Dunnett's multiple comparison test (two tailed).