Table 2.
Voltage-dependent effects of flecainide on KV4.3 channels activation and inactivation
|
Voltage-dependence of activation |
||||
|---|---|---|---|---|
| Vh (mV) | Slope (mV) | |||
| Control | Flecainide | Control | Flecainide | |
| KV4.3/KChIP2 (n=11) | 13.1±3.3 | 1.6±3.7* | 11.1±0.7 | 9.7±0.4 |
| +MiRP1 (n=7) | 19.0±4.8 | 12.4±5.5* | 13.5±0.9 | 11.9±1.4 |
| +DPP6 (n=8) | 2.2±3.3# | −9.5±4.4** | 11.2±1.9 | 10.6±1.2 |
| +MiRP1+DPP6 (n=6) | 2.0±1.6# | −7.7±3.9* | 13.6±2.4 | 11.2±2.1 |
|
Voltage-dependence of inactivation |
||||
| Vh (mV) |
Slope (mV) |
|||
| |
Control |
Flecainide |
Control |
Flecainide |
| KV4.3/KChIP2 (n=9) | −18.2±2.5 | −22.1±3.2* | 4.9±0.6 | 3.8±0.6 |
| +MiRP1 (n=11) | −15.0±1.9 | −20.0±2.1** | 6.4±0.6 | 4.9±1.0 |
| +DPP6 (n=7) | −27.3±2.0# | −36.7±4.6* | 5.2±0.2 | 4.1±0.3 |
| +MiRP1+DPP6 (n=6) | −28.2±1.9# | −31.7±2.1* | 4.4±0.5 | 3.5±0.4 |
Abbreviations: DPP6, dipeptidyl-aminopeptidase-like protein 6; MiRP1, minK-related peptide 1.
*
P<0.05 vs control.
**
P<0.01 vs control.
#
P<0.05 vs KV4.3/KChIP2 and +MiRP1 channels.