Table 1.

DNAzymes and in vivo cardiovascular pathologies.

Target	DNAzyme	Model	Effect	References
Egr-1	ED5 3′-TAGCAGGTCCAGCAACATCCATCGGACCGGCGCC-5 (inverted 3′ T)	Rat and pig ballon catheter injury	Inhibition of neointima formation	Santiago et al., 1999a, 1999b, 1999c; Bhindi et al., 2006
		Rat myocardial ischaemia-reperfusion injury	Attenuation of infarct size and inflammatory mediators
c-jun	Dz13 3′-TGTTGCGGAAGCAACATCGATCGGAAGGAGGGC-5′ (inverted 3′ T)	Rat carotid artery ligation	Inhibition of neointima formation	Khachigian et al., 2002
TNF-α	Active TNFα Dz 3′-TsTsTsCsCsTsGsTsGsGAGCAACATCGGAsCsTsCsGsTsG-5′	Rat AMI by LAD ligation	Increased cardiac output	Iversen et al., 2001
PAI-1	E2 3′-TACGTCTAAGCAACATCGATCGGAGAAGTCG-5′ (inverted 3′ T)	Rat AMI by LAD ligation	Enhanced neovascularization, cardiomyocyte regeneration and function recovery with angioblast coinjection	Xiang et al., 2005a, 2005b
VDUP1	E4 3′-TCGAGTTAGAGCAACATCGATCGGACCACTAC-5′ (inverted 3′ T)	Rat AMI by LAD ligation	Decreased apoptosis and collagen expression, increased function	Xiang et al., 2005a, 2005b

Abbreviations: AMI, acute myocardial infarction; Egr-1, early growth response factor-1; LAD, left anterior descending coronary artery; PAI-1, plasminogen activator inhibitor; TNF-α, tumour-necrosis factor; VDUP1, vitamin D3-regulated protein-1.