Figure 1.

Domain structures of Ca²⁺/calmodulin-dependent protein kinase phosphatase (CaMKP) and CaMKP-N. (a) The domain structures of rat protein phosphatase 2Cα (PP2Cα) and CaMKP are shown. Phosphatase domains of PP2Cα and CaMKP, which show modest sequence homology (light grey, 28% identity), were aligned with the PP2C motifs located within these regions being indicated (hatched bar). A Glu cluster located within the N-terminal domain of CaMKP (101–109, filled bar) is also shown. (b) The domain structures of human CaMKP and human CaMKP-N are shown. Regions of human CaMKP and CaMKP-N, which show significant sequence homology (dark grey, 52% identity), were aligned with the PP2C motifs located within the indicated regions (hatched bar). Cluster sequences with acidic amino acids located within the N-terminal regions of human CaMKP and CaMKP-N are also shown (filled bar).