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. 2008 Apr 14;154(4):749–757. doi: 10.1038/bjp.2008.116

Figure 5.

Figure 5

Endothelium-dependent dilatation in response to ACh (control) of pressurized (60 mm Hg) cerebral arteries isolated from 6-month-old WT (n=11–12) (a), DL (n=8) (b) and DL+IVA (n=7–8) (c) mice. The effects of H2O2 inactivation by catalase (100 U ml−1) and COX inhibition by INDO (10 μM) were tested in separate segments of cerebral arteries isolated from the same animal. DL+IVA mice were treated with ivabradine (IVA, 10 mg kg−1 day−1) from the age of 3–6 months. Data are mean±s.e.mean. ‡P<0.05 compared with the control. ACh, acetylcholine; COX, cyclooxygenase; DL, dyslipideamic; DL+IVA, dyslipidaemic mice treated with ivabradine; INDO, indomethacin; WT, wild type.