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. 2008 Apr 14;154(4):749–757. doi: 10.1038/bjp.2008.116

Figure 6.

Figure 6

The effects of chronic treatment, from the age of 3-months, with ivabradine (IVA) and metoprolol (METO) on (a) the increase (%) in heart rate (HR) measured under anaesthesia in DL mice observed at 4.5 and 6 months of age. (b and c) Endothelium-dependent dilator responses to ACh of pressurized renal (b) and cerebral (c) arteries, preconstricted with phenylephrine, isolated from 6-month-old WT (n=13 and 12), DL (n=13 and 8) and DL+METO (n=13 and 13, respectively) mice. DL+METO mice were treated with metoprolol (80 mg kg−1 day−1) from the age of 3–6 months. Data are mean±s.e.mean. ‡P<0.05 compared with WT; *P<0.05 compared with DL. ACh, acetylcholine; DL, dyslipideamic; WT, wild type.