Table 1.

Heart rate (beats min⁻¹) of WT, DL and DL+IVA mice measured under isoflurane anaesthesia at 3, 4.5 and 6 months of age

Age (months)	WT	n	DL	n	DL+IVA	n
3	385±8	15	373±9	16	385±10	17
4.5	405±11	15	431±14*	13	375±13§	16
6	381±15	15	465±10*,‡	10	422±11*,†,‡,§	14

Abbreviations: DL, dyslipidaemic mice; DL+IVA, dyslipidaemic mice treated with ivabradine; WT, wild-type mice.

DL+IVA mice were treated with ivabradine (IVA, 10 mg kg⁻¹ day⁻¹) from the age of 3 to 6 months. Data are mean±s.e.mean. ^*P<0.05 compared with 3 months; ^†P<0.05 compared with 4.5 months; ^‡P<0.05 compared with the WT; ^§P<0.05 compared with DL. n refers to the number of animals used in each group.