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. 2008 Apr 14;154(4):749–757. doi: 10.1038/bjp.2008.116

Table 3.

Basal vascular parameters in control conditions of pressurized (100 mm Hg) renal arteries isolated from WT (n=14), DL (n=8–14) and DL+IVA (n=9–16) mice

Groups Dmax (μm) Myogenic tone (% of Dmax) Contraction to PE 10 μM (% of Dmax) Contraction to high K+ (% of Dmax)
WT 385±22 33±3 64±2 66±3
DL 399±20 16±3* 64±3 61±4
DL+IVA 403±16 9±2* 64±3 68±3

Abbreviations: DL, dyslipidaemic mice; DL+IVA, dyslipidaemic mice treated with ivabradine; Dmax, maximal diameter; high K+, 40 mM KCl physiological solution; PE, phenylephrine; WT, wild-type mice.

DL+IVA mice were treated with ivabradine (IVA, 10 mg kg−1 day−1) from the age of 3–6 months. Data are mean±s.e.mean. *P<0.05 compared with the WT.