Table 5.
Basal vascular parameters in control conditions of pressurized (60 mm Hg) cerebral arteries isolated from WT (n=12), DL (n=8–9) and DL+IVA (n=6–8) mice
| Groups | Dmax (μm) | Myogenic tone (% of Dmax) | Contraction to PE 10 μM (% of Dmax) | Contraction to high K+ (% of Dmax) |
|---|---|---|---|---|
| WT | 190±5 | 18±2 | 48±3 | 60±4 |
| DL | 216±6 | 15±2 | 50±3 | 55±2 |
| DL+IVA | 212±5 | 16±4 | 55±4 | 61±5 |
Abbreviations: DL, dyslipidaemic mice; DL+IVA, dyslipidaemic mice treated with ivabradine; Dmax, maximal diameter; high K+, 40 mM KCl physiological solution; PE, phenylephrine; WT, wild-type mice.
DL+IVA mice were treated with ivabradine (IVA, 10 mg kg−1 day−1) from the age of 3–6 months. Data are mean±s.e.mean.