Figure 2.

Inhibition of spontaneous synaptic activity by chemokines. (A) [Ca²⁺]_i oscillations were blocked by hMDC and mMDC, fractalkine, RANTES, and SDF-1α in different neurons. In total, 18 of 37 oscillating neurons were responsive to mMDC (10 nM), 19 of 20 to fractalkine (100 nM), 7 of 7 to RANTES (50 nM), and 17 of 17 to SDF-1α (50 nM). (B) Fractalkine (50 nM) reduced the frequency, but not the amplitude, of excitatory postsynaptic currents recorded from hippocampal neurons (7 of 9 neurons). Similar results were obtained with mMDC (data not shown; 3 of 7 neurons). ∗ = P < 0.001 paired Student’s t test.