Table 5.
Independent clinical correlates of cerebrovascular diagnoses after graft failurea
| Characteristics | Ischemic Stroke (aHR [95% CI]) | Hemorrhagic Stroke (aHR [95% CI]) | TIA (aHR [95% CI]) | Any CVE Diagnosis (aHR [95% CI]) |
|---|---|---|---|---|
| Candidate traits | ||||
| age (yr) | ||||
| 18 to 44 | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | |
| 45 to 60 | 2.34 (1.51 to 3.62)b | 1.96 (1.26 to 3.07)b | 1.98 (1.47 to 2.66)c | |
| >60 | 3.02 (1.84 to 4.95)c | 3.37 (2.09 to 5.42)c | 2.71 (1.93 to 3.80)c | |
| race | ||||
| white | – | – | 1.00 (Reference) | |
| other | – | – | 0.27 (0.09 to 0.83)d | |
| cause of ESRD | ||||
| diabetes | 1.95 (1.31 to 2.90)b | 1.88 (1.26 to 2.81)b | 1.75 (1.31 to 2.33)b | |
| other causes | 1.00 (Reference) | 1.00 (Reference) | 1.00 (Reference) | |
| Baseline recipient comorbidities | ||||
| congestive heart failure | 2.51 (1.33 to 4.74)b | – | 1.89 (1.14 to 3.13)d | |
| Donor traits | ||||
| race | ||||
| white | – | – | 1.00 (Reference) | |
| other | – | – | 0.16 (0.04 to 0.65)d | |
| Transplantation factors | ||||
| sensitized recipient | 2.16 (1.37 to 3.39)b | – | 1.65 (1.17 to 2.32)b |
Final models determined by Cox regression with stepwise selection. NS categorical strata were collapsed into reference groups by the selection procedure (e.g., age groups of 18 to 30 and 31 to 44 yr, causes of ESRD other than diabetes). Adjustment covariates considered in the analysis but not significantly related to any outcome were recipient gender, ethnicity, education, BMI, coronary artery disease, arrhythmia, peripheral vascular disease, chronic obstructive pulmonary disease, smoking history, and alcohol abuse history; donor type, gender, hypertension, and death as a result of cerebrovascular accident; and HLA match, delayed graft function, immunosuppression, and cause of graft failure.
P < 0.01.
P < 0.001.
P < 0.05.