Table 3.
Adjusted correlates of transplantation without cardiac evaluation by multivariable logistic regressiona
| Characteristic | Full Cohort [adjusted odds ratio (95% CI)] | High Risk [adjusted odds ratio (95% CI)] | Lower Risk [adjusted odds ratio (95% CI)] |
|---|---|---|---|
| Age | |||
| 18–30 yr | 6.84 (6.11–7.65) | 3.24 (2.80–3.76) | 19.89 (16.43–24.07) |
| 31–44 yr | 2.89 (2.64–3.16) | 1.81 (1.63–2.02) | 7.18 (6.11–8.43) |
| 45–60 yr | 1.77 (1.62–1.93) | 1.50 (1.35–1.66) | 2.64 (2.25–3.11) |
| >60 yr | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Female gender | 1.12 (1.06–1.19) | 1.08 (1.00–1.17) | 1.34 (1.20–1.49) |
| Race | |||
| black | 1.39 (1.29–1.49) | 1.41 (1.29–1.54) | 1.20 (1.06–1.35) |
| white | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| other | 1.33 (1.16–1.52) | 1.31 (1.10–1.57) | 1.00 (reference) |
| BMI at transplant | |||
| underweight | 1.36 (1.15–1.61) | 1.00 (reference) | 1.66 (1.24–2.22) |
| normal weight, overweight, or obese | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| not available | 1.21 (1.13–1.30) | 1.16 (1.06–1.26) | 1.22 (1.10–1.39) |
| Cause of ESRD | |||
| diabetes | 0.48 (0.43–0.54) | 0.52 (0.46–0.58) | – |
| hypertension | 0.74 (0.69–0.81) | 0.79 (0.71–0.88) | 0.75 (0.67–0.85) |
| other causes | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Pretransplant dialysis duration | |||
| 1–12 mo | 8.15 (7.18–9.24) | 8.00 (6.74–9.49) | 8.14 (6.64–9.99) |
| 13–24 mo | 3.48 (3.10–3.92) | 3.43 (2.92–4.04) | 3.54 (2.94–4.26) |
| 25–60 mo | 1.92 (1.72–2.15) | 1.82 (1.55–2.13) | 2.03 (1.71–2.41) |
| >60 mo | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| Diabetes mellitus | 0.61 (0.55–0.67) | 0.82 (0.73–0.92) | – |
| Ischemic heart disease | 0.21 (0.19–0.23) | 0.23 (0.21–0.25) | – |
| Congestive heart failure | 0.55 (0.51–0.59) | 0.64 (0.59–0.69) | 0.35 (0.30–0.41) |
| Cerebral vascular disease | 0.82 (0.72–0.94) | 0.87 (0.76–1.00) | 0.56 (0.36–0.87) |
| Peripheral vascular disease | 0.76 (0.71–0.81) | 0.77 (0.72–0.84) | 0.74 (0.62–0.87) |
| Dyslipidemia | 0.77 (0.67–0.88) | – | – |
| transplant era | |||
| 1991–1995 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| 1996–1999 | 1.11 (1.04–1.18) | 1.15 (1.07–1.25) | 1.00 (reference) |
| 2000–2004 | 1.00 (reference) | 1.00 (reference) | 0.77 (0.68–0.87) |
| Region | |||
| 1 | 0.75 (0.64–0.89) | 0.77 (0.62–0.96) | 1.00 (reference) |
| 2 | 0.81 (0.73–0.89) | 0.86 (0.76–0.97) | 1.00 (reference) |
| 3 | 1.39 (1.27–1.52) | 1.39 (1.25–1.55) | 1.84 (1.58–2.15) |
| 4 | 1.00 (reference) | 1.26 (1.11–1.44) | 1.20 (1.00–1.42) |
| 5 | 1.38 (1.26–1.52) | 1.31 (1.17–1.48) | 1.88 (1.61–2.21) |
| 6 | 1.00 (reference) | 1.00 (reference) | 1.40 (1.05–1.86) |
| 7 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| 8 | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| 9 | 1.00 (reference) | 1.26 (1.05–1.51) | 1.00 (reference) |
| 10 | 0.89 (0.80–1.00) | 1.00 (reference) | 1.00 (reference) |
| 11 | 1.00 (reference) | 1.00 (reference) | 1.41 (1.19–1.68) |
a
Effect estimates reflect the adjusted odds of transplantation without cardiac evaluation associated with a given trait compared with the reference trait within each sample (full cohort, high risk, lower risk). Nonsignificant categorical strata were collapsed into reference groups by the stepwise selection procedure in logistic regression, thus resulting in differing regional reference groups in the three models.