Table 3.
Mean (SD) pharmacokinetic parameters of epoetin alfa (pharmacokinetically assessable population)a
| Pharmacokinetic Parameter | 50 IU/kg Three Times Weekly for 4 wk(n = 10) | 10,000 IU Weekly for 4 wk(n = 7) | 20,000 IU Every 2 wk for 4 wk(n = 9) | 40,000 IU Every 4 wk for 8 wk(n = 10) |
|---|---|---|---|---|
| Cmax (mU/ml; mean [SD]) | 75.9 (18.1) | 193 (104) | 368 (166) | 1246 (647) |
| tmax (h; median [range]) | 12.0 (9.0 to 27.0) | 24.0 (12.0 to 24.0) | 24.0 (12.0 to 72.0) | 24.0 (24.0 to 27.0) |
| AUClast (mU × h/ml; mean [SD]) | 3565 (1157)b | 10,419 (4377)c | 25,275 (14,418)d | 68,908 (27,238)e |
| t1/2 (h; mean [SD]) | 43.2 (7.65)f | 28.7 (9.94) | 30.6 (22.5) | 27.2 (17.6)f |
| CL/F (ml/h; mean [SD]) | 1386 (425) | 1103 (425) | 961 (450)g | 600 (193)g |
a
CL/F, total apparent clearance; Cmax, maximum observed concentration; t1/2, half-life; tmax, time of maximal concentration.
b
Data to approximately 72 h.
c
Data to approximately 168 h.
d
Data to approximately 336 h.
e
Data to approximately 672 h.
f
n = 9.
g
n = 7.\