Table 5.
Mean (SD) overall pharmacodynamic response (pharmacodynamically assessable population)a
| Pharmacodynamic Parameter | 50 IU/kg Three Times Weekly for 4 wk(n = 9) | 10,000 IU Weekly for 4 wk(n = 7) | 20,000 IU Every 2 wk for 4 wk(n = 8) | 40,000 IU Every 4 wk for 8 wk(n = 10) |
|---|---|---|---|---|
| Reticulocytes (% × h) | ||||
| AUR1 wk | 110 (34.9) | 130 (66.0) | 144 (49.6)b | 161 (85.6) |
| AUR2 wk | 349 (89.4) | 387 (228) | 375 (45.8)c | 402 (249)d |
| AUR4 wk | 597 (208)e | 645 (151)e | 959 (243)e | 458 (336)b |
| Hemoglobin (g × h/dl) | ||||
| AUR1 wk | 48.3 (40.7) | 5.31 (10.5) | 32.7 (37.3)b | 42.2 (44.3) |
| AUR2 wk | 149 (108) | 70.7 (62.9) | 90.1 (95.4) | 141 (108)f |
| AUR4 wk | 406 (217) | 328 (227) | 365 (251) | 391 (218)f |
| Total red blood cell count (× 106 × h/μl) | ||||
| AUR1 wk | 15.9 (15.3) | 4.29 (7.71) | 11.8 (13.0)b | 19.8 (19.5) |
| AUR2 wk | 45.2 (43.5) | 32.8 (24.3)g | 33.7 (31.0) | 62 (44.6)f |
| AUR4 wk | 123 (109) | 119 (92.4)g | 130 (92.7) | 157 (86.1)f |
a
AUR, area under the response-time curve.
b
n = 7.
c
n = 5.
d
n = 8.
e
n = 4.
f
n = 9.
g
n = 6.