Table 2.

The 37 urinary biomarkers that statistically differentiated 104 patients randomly selected from the group of 147 patients with nondiabetic chronic renal diseases from a cohort composed of 70% of patients with clinically confirmed diabetic nephropathy^a

Polypeptide			P			Diabetic Nephropathy		Nondiabetic Chronic Renal Disease		Sequence	Protein
ID	Mass (Da)	CE Time (min)	Unadjusted	maxT	Bonferroni	Frequency	Mean Amplitude	Frequency	Mean Amplitude
175343b	5574.25	23.20	8.77E-06	0.0213	5.01E-03	0.55	1.55	0.43	1.06
140401b	3669.67	24.17	1.90E-07	0.0017	1.10E-04	0.82	2.51	0.48	1.26
140112	3657.67	40.71	1.07E-05	0.0175	6.23E-03	0.32	0.82	0.72	1.95
130855b	3363.54	30.22	8.03E-08	0.0006	4.66E-05	0.80	2.1	0.42	0.94
129940	3333.72	23.83	3.34E-06	0.0456	1.91E-03	0.55	1.53	0.29	0.67
121444	3081.42	29.83	1.69E-05	0.0301	9.82E-03	0.23	0.45	0.52	1.24
110175b	2802.82	36.34	3.94E-14	0.0001	2.29E-11	0.07	0.14	0.56	1.31
107858b	2751.34	29.23	1.14E-06	0.0043	6.62E-04	0.20	0.52	0.61	1.52
107763b	2748.79	36.38	8.12E-15	0.0001	4.72E-12	0.09	0.14	0.60	1.18
107016	2733.78	34.16	8.38E-12	0.0001	4.87E-09	0.07	0.14	0.52	1.13
99251	2574.01	32.81	3.86E-07	0.0027	2.24E-04	0.16	0.29	0.53	1.04
97736	2551.15	34.72	8.65E-06	0.0315	4.94E-03	0.57	1.24	0.84	2.09
90344	2377.10	20.80	1.29E-05	0.0185	7.49E-03	0.45	1.17	0.77	2.29	GKNGDDGEAGKhPGRPhGERGPPhGPQ	Collagen α-1 (I) chain (227 to 250; Homo sapiens)
88282	2339.00	34.01	3.74E-05	0.0438	2.18E-02	0.52	1.21	0.82	2.21
80012b	2191.99	22.39	6.40E-12	0.0001	3.72E-09	0.14	0.31	0.63	1.62	NGDDGEAGkPGRpGERGPpGPQ	Collagen α-1 (I) chain
72521b	2046.81	30.72	1.89E-05	0.0351	1.10E-02	0.23	0.45	0.51	1.26
72161b	2039.13	21.78	1.92E-13	0.0001	1.11E-10	0.14	0.31	0.61	1.83	SGSVIDQSRVLNLGPITRK	Uromodulin (589 to 607; Homo sapiens)
67382	1936.87	34.75	1.53E-05	0.0275	8.89E-03	0.20	0.4	0.53	1.13	GEKGPSGEAGTAGPPGTPGPQG	Collagen α-2 (I) chain (844 to 865; Homo sapiens)
64905	1893.03	28.86	3.02E-05	0.0429	1.75E-02	0.27	0.65	0.63	1.57
64431b	1885.65	38.82	1.73E-05	0.0276	1.01E-02	0.23	0.47	0.61	1.29
63427b	1865.81	32.98	2.73E-09	0.0003	1.59E-06	0.18	0.34	0.62	1.31	DAGPAGPKGEPhGSPhGENGAPhG	Collagen α-1 (I) chain (279 to 299; Homo sapiens)
62387	1844.48	34.27	3.82E-07	0.0025	2.22E-04	0.18	0.43	0.58	1.39
57265b	1732.77	28.18	1.08E-06	0.0023	6.30E-04	0.55	1.69	0.93	3.04
56884b	1725.59	38.32	5.12E-05	0.0494	2.97E-02	0.52	1.52	0.88	2.62
56514	1716.77	28.00	3.09E-06	0.0060	1.79E-03	0.45	1.04	0.79	2.07
55637b	1698.57	37.73	3.60E-06	0.0082	2.09E-03	0.27	0.68	0.63	1.79
45863	1549.70	39.49	2.28E-05	0.0366	1.32E-02	0.18	0.43	0.53	1.21
44802	1526.69	23.92	2.62E-06	0.0065	1.52E-03	0.23	0.48	0.62	1.31
42378	1486.68	21.15	1.39E-09	0.0002	8.09E-07	0.11	0.28	0.59	1.35
42304b	1485.67	23.77	7.18E-06	0.0072	4.17E-03	0.64	1.76	0.94	2.81	DGQPhGAKGEPhGDAGAK	Collagen α-1 (I) chain (820 to 835; Homo sapiens)
36350	1396.62	26.67	1.04E-05	0.0194	6.01E-03	0.18	0.38	0.53	1.07
33973	1353.66	25.63	2.10E-05	0.0241	1.22E-02	0.61	1.31	0.87	2.16
32470	1326.55	29.20	1.18E-06	0.0044	6.86E-04	0.23	0.48	0.62	1.36	SpGGpGSDGKpGPpG	Collagen type 3 α1
32343	1324.59	28.70	7.45E-07	0.0032	4.33E-04	0.77	2.04	0.40	0.95	TGPGGDKGDTGPpGP	Collagen α-1 (III) chain
20750	1141.52	24.51	1.89E-07	0.0017	1.10E-04	0.20	0.39	0.59	1.29
19791b	1128.49	25.65	1.48E-08	0.0003	8.59E-06	0.34	0.76	0.81	1.93
16497b	1078.47	27.76	1.01E-05	0.0195	5.89E-03	0.25	0.46	0.55	1.20

^aShown are the protein/peptide identification number in the data set (ID), mass (in Da) and normalized migration time (CE Time), the P values (unadjusted and adjusted using maxT and Bonferroni), and the frequency and mean amplitude in the two groups, diabetic nephropathy (DN) and other chronic renal disease (CRD). Where available, sequence and original protein are shown.

^bSubsequently used in the classification model.