Table 2.

Factors associated with NOD^a

Factor	HR	95% CI	P
CSA + MMF/Aza	1.00
TAC + MMF/Aza	1.40	1.29 to 1.52	<0.0001
Sirolimus + MMF/Aza	1.36	1.09 to 1.69	<0.0100
Sirolimus + CSA	1.61	1.36 to 1.90	<0.0001
Sirolimus + TAC	1.66	1.42 to 1.93	<0.0001
Age (yr)
18 to 44	0.57	0.52 to 0.62	<0.0001
45 to 59	1.00
≥60	1.30	1.19 to 1.42	<0.0001
Female gender	1.07	1.00 to 1.15	0.0800
Race
white	1.00
black	1.56	1.43 to 1.71	<0.0001
other	1.20	1.02 to 1.42	0.0300
Hispanic ethnicity	1.48	1.33 to 1.65	<0.0001
Acute rejection in first year
No acute rejection	1.00
Acute rejection in first year	1.37	1.24 to 1.51	<0.0001
Cause of ESRD
glomerulonephritis	1.00
hypertension	1.22	1.12 to 1.34	<0.0001
polycystic disease	1.02	0.90 to 1.16	0.7600
other	1.22	1.12 to 1.33	<0.0001
Duration of dialysis (yr)
0 to 1	1.00
1 to 3	1.04	0.99 to 1.09	0.1400
>3	1.00	0.89 to 1.13	0.9500
BMI (kg/m2)
<25	1.00
25 to 30	1.29	1.18 to 1.41	<0.0001
>30	1.65	1.50 to 1.82	<0.0001
Hepatitis C positive	1.70	1.49 to 1.94	<0.0001
Comorbid conditions
ischemic heart disease	1.18	1.01 to 1.38	0.0400
cerebrovascular disease	0.91	0.71 to 1.17	0.4700
peripheral vascular disease	1.18	0.93 to 1.50	0.1800
congestive heart failure	1.22	1.07 to 1.37	<0.0100
Deceased donor	1.21	1.06 to 1.37	<0.0100
Preemptive transplant	0.85	0.73 to 1.00	0.0500
HLA mismatch
0	1.00
1 to 3	1.11	0.93 to 1.33	0.2400
4 to 6	1.11	0.93 to 1.33	0.2300
Transplantation era
1995 to 1997	1.00
1998 to 2000	1.23	1.08 to 1.39	<0.0100
2001 to 2003	0.82	0.72 to 0.94	<0.0100
Corticosteroid use at hospital discharge after transplantation	0.91	0.72 to 1.15	0.4300

^aBased on maintenance immunosuppressant drug combination at the time of transplantation.