Table 3.

Factors associated with NOD among 16,861 patients treated with the same immunosuppressant drug combinations throughout the first posttransplantation year

Factor	HR	95% CI	P
Drug combination throughout first transplantation year
CSA + MMF/Aza	1.00
TAC + MMF/Aza	1.40	1.28 to 1.54	<0.0001
Sirolimus + MMF/Aza	1.14	0.80 to 1.61	0.4600
Sirolimus + CSA	1.78	1.44 to 2.21	<0.0001
Sirolimus + TAC	1.76	1.44 to 2.16	<0.0001
Age (yr)
18 to 44	0.56	0.51 to 0.62	<0.0001
45 to 59	1.00
≥60	1.31	1.18 to 1.45	<0.0001
Female gender	1.08	0.99 to 1.18	0.0600
Race
white	1.00
black	1.55	1.40 to 1.72	<0.0001
other	1.25	1.04 to 1.50	0.0200
Hispanic ethnicity	1.48	1.31 to 1.67	<0.0001
Corticosteroid use at transplantation and at 1 yr
no/no (n = 202, 1.2%)	1.00
yes/no (n = 1197, 7.1%)	0.98	0.61 to 1.56	0.9300
no/yes (n = 152, 0.9%)	2.05	1.18 to 3.57	0.0100
yes/yes (n = 15,310, 90.8%)	1.37	0.88 to 2.12	0.1700
Acute rejection in first year
no acute rejection	1.00
acute rejection in first year	1.31	1.16 to 1.48	<0.0001
Cause of ESRD
glomerulonephritis	1.00
hypertension	1.25	1.12 to 1.38	<0.0001
polycystic disease	1.04	0.90 to 1.19	0.6300
other	1.18	1.05 to 1.31	<0.01
Duration of dialysis (yr)
0 to 1	1.00
1 to 3	1.03	0.97 to 1.09	0.3600
>3	0.94	0.82 to 1.07	0.3500
Preemptive transplant	0.82	0.69 to 0.98	0.0300
BMI (kg/m2)
<25	1.00
25 to 30	1.32	1.17 to 1.44	<0.0001
>30	1.66	1.49 to 1.85	<0.0001
Hepatitis C positive	1.72	1.48 to 2.01	<0.0001
Transplantation era
1995 to 1997	1.00
1998 to 2000	1.25	1.09 to 1.44	0.3600
2001 to 2003	0.85	0.73 to 0.99	0.0400
Deceased-donor type	1.21	1.10 to 1.33	0.0001
HLA mismatch
0	1.00
1 to 3	1.15	0.95 to 1.40	0.1600
4 to 6	1.11	0.91 to 1.35	0.2700
Comorbidity
ischemic heart disease	1.13	0.94 to 1.35	0.2000
cerebrovascular disease	0.92	0.69 to 1.21	0.5400
peripheral vascular disease	1.12	0.85 to 1.47	0.4300
cardiac failure	1.20	1.04 to 1.39	0.0100