Figure 2.

(A and B) LPS preconditioning: Pol II levels at start and end exons¹,⁴ of the TNF-α gene. Pol II levels at TNF-α exon 1 (A) and exon 4 (B) were assessed at 15, 30, or 90 min after LPS injection in control (C) or LPS-PC mice. In each instance, Pol II recruitment was observed. The degree of this recruitment was significantly greater in the LPS-PC mice, compared with that seen in the LPS-challenged naive controls (*overall statistical comparison at the three time points at exon 4; P < 0.001).