Figure 7.

(A and B) Maleate nephrotoxicity: Pol II expression at start (A) and end (B) exons of TNF-α, MCP-1, and HO-1 genes. Maleate did not independently alter Pol II levels at either the start or end exons of any of the three assessed genes; however, when injected with LPS, Pol II recruitment occurred and was greater at both exons of the TNF-α and MCP-1 genes, compared with the recruitment seen in the controls. Conversely, no preferential recruitment of Pol II was seen at either exon of the HO-1 gene. Thus, these data were highly analogous to the observed corresponding mRNA levels, as presented in Figure 6A.