Table 3.

Selected signaling pathways detected in the mid-foregut.

		Average Signal					Average Signal
Gene	Affymetrix I	16–20s	21–25s	26–30s	Gene	Affymetrix	16–20s	21–25s	26–30s
FGF pathway					Retinoic Acid pathway
FGF1	1450869_at	160	169	98 t	Crabp1	1448326_a_	1329	508	338
FGF7	1422243_at	111	113	116	Crabp2	1451191_at	881	543	481 t
FGF13	1418497_at	570	664	743	Rai1	1453200_at	255	416	315
FGFRII	1420847_a_	164	155	155	Rai12	1431411_a_	1496	1135	993
FGFRIII	1421841_at	375	399	441	Stra13	1433574_at	141	115	147
FGFRV	1451912_a_	144	248	190	Raet1a	1420603_s_	532	300	295
FGFRap1	1424615_at	346	321	427
Bmp pathway					Notch pathway
Bmp1	1426238_at	347	355	407	Notch1	1418634_at	185	480	203 a
Bmp4	1422912_at	304	337	434	Notch2	1455556_at	896	876	603
Bmp7	1435479_at	361	413	452	Notch3	1421965_s_	1069	1151	1069
BmpR1a	1425491_at	248	266	296	Dll1	1419204_at	179	275	252
BmpR1a	1425492_at	2055	3039	2974	Dll3	1449236_at	100	204	250 t
BmpR1a	1425493_at	307	530	473	Dtx2	1439429_x_	1956	1833	1867
BmpR1a	1425494_s_	535	1009	780	Dtx3	1420752_at	229	258	289
BmpR1a	1451729_at	426	421	326	Psen1	1421853_at	1064	1161	1079
Smad1	1448208_at	815	1251	1215	Psenen	1415679_at	2563	1924	1299 a
Smad5	1451873_a_	189	279	233	Rbpsuh	1448957_at	402	691	719
Grem1	1425357_a_	147	125	80 a,t	Maml1	1426769_s_	931	1438	1253
Bambi	1423753_at	901	674	548	Mib1	1451818_at	278	267	235
Bmp2k	1437419_at	111	169	290	Mib2	1424862_s_	202	193	160
					Sbno1	1426559_at	135	334	143
Shh/Ptch pathway					Sbno1	1434612_s_	276	417	359
Ptch	Ptch	Ptch	Ptch	Ptch	Sbno1	1451436_at	186	255	258
Smo	Smo	Smo	Smo	Smo	App	1420621_a_	184	212	180
Smo	Smo	Smo	Smo	Smo	App	1427442_a_	3160	4941	3498
Gli1	Gli1	Gli1	Gli1	Gli1	Aph1a	1424979_at	217	216	217
Gli2	Gli2	Gli2	Gli2	Gli2	Aph1a	1424980_s_	569	378	547
Gli2	Gli2	Gli2	Gli2	Gli2	Aph1a	1451554_a_	238	216	192 a
Hhip	Hhip	Hhip	Hhip	Hhip	Fbxw7	1451558_at	499	426	539
Hhip	Hhip	Hhip	Hhip	Hhip	Il6st	1452843_at	348	521	325
Zic1	Zic1	Zic1	Zic1	Zic1	Nrarp	1417985_at	395	527	512
					Trp63	1418158_at	130	141	125
					Wdr12	1448646_at	729	735	501

t= Student’s t-test p ≤ 0.05

a= ANOVA p ≤ 0.05

The table includes the average signal for genes detected in the mid-foregut and lung regions (detection p ≤ 0.05) at 16–20s, 21–25s and 26–30s developmental stages. Only genes with a signal ≥ 100 at any stage are listed. Most genes do not change the level of expression as the lung buds. A few of them change the level of expression significantly indicated by Student’s t and/or ANOVA tests.