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. Author manuscript; available in PMC: 2008 Jun 26.
Published in final edited form as: Biochemistry. 2007 Nov 29;46(51):15089–15102. doi: 10.1021/bi7018783

Table 5.

The Effects of the Inhibitors on the Thermal Stability of GDHa

compound rate (min−1) R2 half-life (min) temp (°C)
no drug 0.020 (0.001) 0.99 34.5 50
bithionol 0.048 (0.002) 0.99 14.4 50
diethystilbestrol 0.202 (0.017) 0.98 3.4 50
palmitoyl CoA 0.169 (0.011) 0.99 4.1 50
CK2 inhibitor 0.048 (0.003) 0.98 14.4 50
GW5074 0.084 (0.016) 0.87 8.2 50
BH3I-2 0.046 (0.006) 0.90 15.0 50
calmidazolium 0.017 (0.031) 0.82 40.6 50
no drug 0.127 (0.019) 0.93 5.4 54
hexachlorophene 0.113 (0.007) 0.98 6.1 54
ATA 0.028 (0.002) 0.94 24.6 54
a

This is a summary of the data shown in Figure 10 and fitted to eq 7.