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. 2008 Jul 2;3(7):e2572. doi: 10.1371/journal.pone.0002572

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Roh et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Percentage of cells showing total chromosome number, numerical and structural aberrations from FACS-sorted hTERT-HME1 cells. Note that karyotypes of polyploid and soft agar derived cells are highly heterogeneous, whereas karyotypes of control Neo and diploid cells are more uniform. Total 13 to 40 metaphase spreads were analyzed per sample and scored for the chromosome number, numerical aberrations, and structural aberrations. (B) Representative SKY images from each FACS-sorted hTERT-HME1 cells. Neo: 45,XX,t(6;17),−17. Diploid: 46,XX,del(5),t(5;8). Polyploid: 89,XXXX,+1,+1,t(1;2),+2,+3,+3,+4,+5,+5,+5,del(5),+6,+6,+7,+7,+8,+8,+9,+9,+10,+10,+11,+11,del(11),+12,+12,+13,+13,+14,+15,+15,+16,+16,+17,+17,t(15;17),+18,+18,+19,+19,+20,+20,+21,+21,+22. Soft agar: 89,XXX,+1,+1,t(1;2),+2,+3,+3,+4,+5,+5,+5,del(5), +6,+6,+7,+7,+8,+8,+8,t(8;20),+9,+9,+10,+10,+11,+11,del(11),+12,+12,+13,+13,+14,+14,+15,+16,+16,+17,+17,+18,+18,+19,+19,+20,+21,+21,+22,+22. (C) Tables showing derivative chromosomes in the different sorted cell types. The numbers of derivative chromosomes observed are shown. Polyploid and soft agar derived cell-specific abnormalities are shown in bold.