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. 2008 Jul 2;3(7):e2572. doi: 10.1371/journal.pone.0002572

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Roh et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Soft agar assay of FACS-sorted diploid and polyploid hTERT-HME1 Pim-1 overexpressing cells and control Neo cells. Note the larger colonies in polyploid cells. Colonies larger than 1 mm in diameter were counted from triplicate of 60 mm dishes. Original magnification: 10×. (B) We isolated cells from soft agar colonies formed by polyploid cells shown in Fig. 7A. The tumorigenic potential of these soft agar-derived polyploid cells was compared side by side with that of the parental polyploid cells by soft agar assay. The soft agar-derived cells formed larger size colonies with higher frequency than the parental polyploid cell population. Original magnification; 4×.