Table 2. Associations between IGFBP1 and IGFBP3 SNPs and mean circulating IGF-I and IGFBP-3 levels in the BPC3.
| SNP | Genotype | N (n = 6,275) | mean IGF1 diff | p-trend | % change | N (n = 6,275) | mean IGFBP-3 diff | p-trend | % change |
| Block 1 | |||||||||
| rs10228265 | AA | 3035 | 26.9 | 0 | 2981 | 122.5 | 0 | ||
| (45649695) | AG | 2654 | 27.3 | 1.4 | 2587 | 121 | −1.2 | ||
| GG | 599 | 27.3 | 0.108 | 1.7 | 585 | 120.3 | 0.083 | −1.8 | |
| rs1553009 | GG | 4061 | 27.1 | 0 | 3976 | 121.5 | 0 | ||
| (45649774) | GA | 1998 | 27.6 | 2 | 1953 | 122.1 | 0.5 | ||
| AA | 235 | 26.5 | 0.285 | −2 | 232 | 124.4 | 0.270 | 2.4 | |
| rs35539615 | CC | 3640 | 27.2 | 0 | 3560 | 121.4 | 0 | ||
| (45653244) | CG | 2269 | 27.1 | −0.2 | 2223 | 121 | −0.3 | ||
| GG | 327 | 27.3 | 0.995 | 0.6 | 319 | 121.5 | 0.788 | 0.1 | |
| rs2201638 | GG | 5854 | 27.2 | 0 | 5729 | 122.1 | 0 | ||
| (45663690) | GA | 413 | 27.6 | 1.7 | 404 | 120.2 | −1.6 | ||
| AA | 17 | 27.7 | 0.349 | 2 | 17 | 113.1 | 0.209 | −8 | |
| rs1065780 | GG | 2358 | 27.0 | 0 | 2309 | 122 | 0 | ||
| (45668457) | GA | 2966 | 27.3 | 1.1 | 2902 | 121.8 | −0.2 | ||
| AA | 923 | 27.3 | 0.262 | 1.1 | 903 | 121.2 | 0.663 | −0.7 | |
| Block 2 | |||||||||
| rs4988515 | CC | 5753 | 27.1 | 0 | 5625 | 121.7 | 0 | ||
| (45673380) | CT | 522 | 27.2 | 0.5 | 515 | 121.1 | −0.5 | ||
| TT | 19 | 26.1 | 0.909 | −3.8 | 19 | 113.9 | 0.532 | −6.8 | |
| rs4619 | AA | 2662 | 27.0 | 0 | 2608 | 122.3 | 0 | ||
| (45673449) | AG | 2839 | 27.2 | 0.5 | 2774 | 121.3 | −0.8 | ||
| GG | 735 | 27.5 | 0.243 | 1.8 | 719 | 122 | 0.543 | −0.2 | |
| rs1908751 | CC | 3113 | 27.2 | 0 | 3047 | 122.2 | 0 | ||
| (45676299) | CT | 2586 | 27.0 | −0.7 | 2526 | 120.6 | −1.3 | ||
| TT | 560 | 27.1 | 0.568 | −0.3 | 552 | 122.6 | 0.486 | 0.3 | |
| rs2270628 | CC | 4121 | 27.3 | 0 | 4038 | 122.8 | 0 | ||
| (45690350) | CT | 1850 | 27.1 | −0.6 | 1804 | 120.1 | −2.2 | ||
| TT | 239 | 27.1 | 0.543 | −0.7 | 234 | 116.4 | 0.001 | −5.5 | |
| Block 3 | |||||||||
| rs3110697 | GG | 2203 | 27.4 | 0 | 2145 | 125.4 | 0 | ||
| (45695809) | GA | 2929 | 27.1 | −1.1 | 2877 | 122.2 | −2.6 | ||
| AA | 1083 | 27.9 | 0.392 | 1.8 | 1059 | 115.2 | <0.0001 | −8.9 | |
| rs2854746 | GG | 2010 | 27.3 | 0 | 1970 | 114.7 | 0 | ||
| (45701425) | GC | 2950 | 27.00 | −0.9 | 2884 | 123 | 7.2 | ||
| CC | 1168 | 27.2 | 0.741 | −0.1 | 1139 | 128.5 | <0.0001 | 12 | |
| rs2854744 | GG | 1586 | 27.6 | 0 | 1550 | 115.6 | 0 | ||
| (45701855) | GT | 3226 | 27.1 | −2.1 | 3169 | 121.5 | 5.1 | ||
| TT | 1427 | 27.6 | 0.745 | −0.3 | 1388 | 127.7 | <0.0001 | 10.5 | |
| Additional SNPs | |||||||||
| rs6670 | TT | 3841 | 27.3 | 0 | 3764 | 121.6 | 0 | ||
| (45693034) | TA | 2146 | 26.8 | −2.1 | 2091 | 120.1 | −1.2 | ||
| AA | 278 | 26.6 | 0.022 | −2.8 | 275 | 125.2 | 0.935 | 3 | |
| rs2453839 | TT | 4046 | 27.3 | 0 | 3964 | 122.3 | 0 | ||
| (45694353) | TC | 1961 | 27.2 | −0.5 | 1917 | 121 | −1.1 | ||
| CC | 250 | 27.5 | 0.901 | 0.9 | 242 | 121.4 | 0.264 | −0.7 | |
| rs2132570 | GG | 3948 | 27.1 | 0 | 2855 | 122.4 | 0 | ||
| (45703243) | GT | 1972 | 27.1 | −0.2 | 1933 | 118.9 | −2.9 | ||
| TT | 291 | 27.5 | 0.812 | 1.3 | 289 | 115.3 | <0.0001 | −6.2 | |
| rs2960436 | GG | 1645 | 27.6 | 0 | 1607 | 115 | 0 | ||
| (45718062) | GA | 3074 | 27.1 | −1.7 | 3021 | 122.5 | 6.5 | ||
| AA | 1547 | 27.3 | 0.431 | −0.9 | 1506 | 127.2 | <0.0001 | 10.6 |